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Chronic & Complex Illness

Long-form reporting on Lyme, autoimmunity, long COVID, and contested diagnoses.

Editor's note

Contested and complex illness — Lyme, autoimmunity, long COVID, ME/CFS — is where patients are most often failed and most often sold to. We report the guideline disagreements in full, including the parts each side prefers to leave out, and we never treat a patient's unresolved symptoms as a rhetorical device.

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Chronic & Complex Illness

Low-Dose Naltrexone: A Small Dose, A Large Set of Claims

A fifty-year-old opioid blocker, prescribed at a tenth of its approved dose for fibromyalgia, long COVID, ME/CFS and MS. The mechanistic story is elegant, the trial record is messier — and 2026 delivered an uncomfortable correction to the field’s most-cited positive number.

Revuelt Health · October 20, 2026 · 10 min read

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Chronic & Complex Illness

Long COVID in 2026: What Actually Helped, and What Still Hasn't

Six years and well over a billion dollars into the federal government's largest long COVID research effort, one trial has produced a durable benefit — and it isn't a drug. A look at what the 2026 data actually supports, and what is still a hypothesis wearing a press release.

Revuelt Health · September 15, 2026 · 10 min read

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A quiet still life on a pale wooden surface in soft morning light: a shallow ceramic dish holding dried seed pods, a folded length of unbleached linen, and a plain glass of water catching the window.

Chronic & Complex Illness

Fecal Transplants Beyond C. diff: What Is Approved, What Is Promising, and What Got Harder to Get

Transferring a healthy person's gut microbes into a sick person's colon is an approved, guideline-backed treatment — for exactly one condition. This year the field finally produced randomized data outside that condition, a regulator said no to the most advanced product in Europe, and a manufactured alternative matched donor stool in a head-to-head trial. None of it points the same direction.

Revuelt Health · September 15, 2026 · 13 min read

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Chronic & Complex Illness

Treatment-Resistant Lyme in 2026: Where the Evidence Actually Stands

Disulfiram disappointed. Dapsone combinations remain uncontrolled. A vaccine missed its endpoint. A field-by-field account of persistent Lyme, without taking a side it hasn't earned.

Revuelt Health · July 28, 2026 · 13 min read

Updated August 7, 2026

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Chronic & Complex Illness

Hyperthermia for Chronic Lyme: The Theory, the Clinics, and the Evidence

Whole-body hyperthermia is offered as a definitive answer for persistent Lyme symptoms. The biological rationale is old; the clinical evidence is thin.

Revuelt Health · July 7, 2026 · 10 min read

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